- Author
-
K.M.A. Smeele
- Title
- The role of mitochondrial hexokinase II in ischemia-reperfusion damage
- Supervisors
- Co-supervisors
-
C.J. Zuurbier
O. Eerbeek - Award date
- 6 July 2012
- Number of pages
- 194
- ISBN
- 9789088914355
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Bij een hartinfarct bepaalt de hoeveelheid onherstelbaar beschadigde hartcellen de prognose van de patiƫnt. Daarom is het noodzakelijk de schade te beperken. In kankercellen is bekend dat het eiwit hexokinase het afsterven van de cellen bemoeilijkt. Kirsten Smeele onderzocht of die beschermende werking bruikbaar kan zijn in het herstel na een hartinfarct. Het blijkt dat in hartspieren van muizen met minder hexokinase meer cellen doodgaan na zuurstoftekort; het eiwit blijkt cruciaal voor de levensvatbaarheid van hartcellen. Het ontrafelen van de onderliggende processen kan leiden tot nieuwe medicijnen die de schade na een hartinfarct door zuurstofgebrek beperken.
- Note
- Research conducted at: Universiteit van Amsterdam
- Persistent Identifier
- https://hdl.handle.net/11245/1.385904
- Downloads
-
Thesis
Cover
Title pages
Table of contents
Chapter 1: General introduction
Chapter 2: The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischemia-reperfusion injury
Chapter 3: Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia-reperfusion injury
Chapter 4: Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice
Chapter 5: Reduced hexokinase II impairs muscle function 2 weeks after ischemia-reperfusion through increased cell necrosis and fibrosis
Chapter 6: Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemiareperfusion
Chapter 7: Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis
Chapter 8: General discussion
Chapter 9: Summary
Chapter 10: Samenvatting
Appendix A: Supplemental material & methods and figures to chapter 3
Appendix B: Supplemental material & methods and figures to chapter 7
Appendix C: Authors and affiliations
Appendix D: Acknowledgements / Dankwoord
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